TY - CHAP M1 - Book, Section TI - Toxic Responses of the Respiratory System A1 - Leikauf, George D. PY - 2012 T2 - Casarett and Doull's Toxicology: The Basic Science of Poisons, 8e AB - Historical PerspectiveRespiratory Tract Structure and FunctionOronasal PassagesStructureSensory FunctionsIrritant, Thermosensory, and Mechanosensory FunctionsConducting AirwaysStructureMucociliary Clearance and Antimicrobial FunctionsGas Exchange RegionStructureFunctionBiotransformation in the Respiratory TractGeneral Principles in the Pathogenesis of Lung Damage Caused by ChemicalsToxic Inhalants, Gases, and DosimetryRegional Particle DepositionDeposition MechanismsParticle ClearanceNasal ClearanceTracheobronchial ClearanceAlveolar ClearanceAlveolar Macrophage ReceptorsAlveolar Macrophage Receptors and Innate ImmunityAlveolar Macrophage Pattern-Recognition ReceptorsAcute Responses of the Lung to InjuryTrigeminally Mediated Airway ReflexesBronchoconstriction, Airway Hyperreactivity, and Neurogenic InflammationAcute Lung Injury (Pulmonary Edema)Chronic Responses of the Lung to InjuryChronic Obstructive Pulmonary DiseaseLung CancerAsthmaPulmonary FibrosisAgents Known to Produce Lung Injury in HumansInhalation HazardsAcroleinAsbestosSilicaNaphthaleneBlood-Borne Agents That Cause Pulmonary Toxicity in HumansBleomycinCyclophosphamide and 1,3 Bis (2-Chloroethyl)-1-Nitrosourea (BCNU)Evaluation of Toxic Lung DamageHumans StudiesAnimals StudiesInhalation Exposure SystemsPulmonary Function Tests in Experimental AnimalsMorphological TechniquesPulmonary Lavage and Pulmonary EdemaIn Vitro StudiesIsolated Perfused LungAirway Microdissection and Organotypic Tissue Culture SystemsLung Cell CultureAcknowledgments SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1100088124 ER -