TY - CHAP M1 - Book, Section TI - Lung Cancer A1 - Heist, Rebecca S. A1 - Sequist, Lecia V. A2 - Murray, Michael F. A2 - Babyatsky, Mark W. A2 - Giovanni, Monica A. A2 - Alkuraya, Fowzan S. A2 - Stewart, Douglas R. PY - 2014 T2 - Clinical Genomics: Practical Applications in Adult Patient Care AB - Disease summary:Lung cancer is the leading cause of cancer mortality in the United States.Approximately 85% of lung cancers are nonsmall cell lung cancer (NSCLC), and about 15% small cell lung cancer (SCLC). Among NSCLC, the incidence of adenocarcinoma is rising to surpass that of squamous cell carcinoma.Presenting symptoms may include shortness of breath, cough, weight loss, or symptoms from a metastatic site such as headache or seizure from a brain metastasis or pain from a bony metastasis. Clinical symptoms typically present late in the course of disease and most patients are diagnosed with advanced lung cancer.NSCLC staging uses the TNM system, in which T stage describes tumor size and location, N stage describes nodal status, and M stage describes metastases—the overall TNM defines if the cancer is stage I, II, III, or IV.SCLC is staged as either limited stage or extensive stage, depending on the extent of the tumor and whether it can fit within a radiation port (limited) or not (extensive). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1102700449 ER -