TY - CHAP M1 - Book, Section TI - Diabetes Mellitus Type 1 A1 - Bar-Lev, Adi A1 - Looker, Helen C. A2 - Murray, Michael F. A2 - Babyatsky, Mark W. A2 - Giovanni, Monica A. A2 - Alkuraya, Fowzan S. A2 - Stewart, Douglas R. PY - 2014 T2 - Clinical Genomics: Practical Applications in Adult Patient Care AB - Disease summary:Diabetes mellitus type 1 (T1DM) is a disorder of insulin secretion which can be subdivided into type 1A (immune mediated) and type 1B (nonimmune mediated).The vast majority of T1DM is type 1A, characterized by both acute and chronic sequelae of hyperglycemia.T1DM has a peak age of onset before the age of 20 years and is the commonest form of diabetes seen in children in the United States.Because insulin production is impaired, T1DM is characterized by an absolute requirement for exogenous insulin and, unlike type 2 diabetes (T2DM), frequently presents as a medical emergency with hyperglycemia, dehydration, and ketoacidosis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1102701092 ER -