RT Book, Section
A1 Weitz, Jeffrey I.
A2 Brunton, Laurence L.
A2 Chabner, Bruce A.
A2 Knollmann, Björn C.
SR Print(0)
ID 1127868083
T1 Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs
T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071624428
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127868083
RD 2023/06/07
AB The  physiological  systems  that  control  the  fluidity  of  blood  are  both  complex  and  elegant.  Blood  must  remain  fluid  within  the  vasculature  and  yet  clot  quickly  when  exposed  to  subendothelial  surfaces  at  sites  of  vascular  injury.  When  intravascular  thrombi  form,  rapid  activation  of  the  fibrinolytic  system  restores  fluidity.  Under  normal  circumstances,  a  delicate  balance  between  coagulation  and  fibrinolysis  prevents  both  thrombosis  and  hemorrhages.  Alteration  of  this  balance  in  favor  of  coagulation  results  in  thrombosis.