RT Book, Section
A1 Byrns, Michael C.
A1 Penning, Trevor M.
A2 Brunton, Laurence L.
A2 Chabner, Bruce A.
A2 Knollmann, Björn C.
SR Print(0)
ID 1127872323
T1 Environmental Toxicology: Carcinogens and Heavy Metals
T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071624428
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127872323
RD 2023/09/27
AB Humans  are  exposed  to  chemicals  from  their  environment  daily.  Fortunately,  mammals  have  evolved  mechanisms  to  protect  themselves  from  toxic  effects  of  many  exogenous  chemicals,  including  the  xenobiotic  transport  and  metabolic  mechanisms  described  in  Chapters  4,5,6,7.  While  the  human  body  is  relatively  well  adapted  to  deal  with  xenobiotics,  there  are  situations  in  which  such  environmental  agents  may  cause  significant  toxicity.  The  industrial  revolution  and  the  development  of  chemical  industries  have  increased  human  exposures  to  chemicals  that  were  previously  infrequent  or  absent.  Occupational  exposures  to  xenobiotics  are  of  particular  concern  because  workers  often  will  be  exposed  to  specific  chemicals  at  concentrations  that  are  orders  of  magnitude  higher  than  those  to  which  the  general  population  is  exposed.  Increasing  concern  about  environmental  toxicants  has  stimulated  interest  and  research  in  environmental  toxicology,  the  study  of  how  chemicals  in  our  environment  adversely  affect  human  health,  and  in  occupational  toxicology,  the  study  of  how  chemicals  in  the  workplace  affect  human  health.  Myriad  authoritative  textbooks  are  available  in  these  areas.  This  chapter  does  not  attempt  a  thorough  coverage;  rather,  it  sets  forth  a  few  basic  principles,  briefly  discusses  carcinogens  and  chemoprevention,  and  then  focuses  on  the  pharmacotherapy  of  heavy  metal  intoxication.