RT Book, Section A1 Renslo, Adam A2 Renslo, Adam SR Print(0) ID 1124842273 T1 Non-Covalent Interactions T2 The Organic Chemistry of Medicinal Agents YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071794213 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1124842273 RD 2024/10/14 AB In the first chapter we described the nature of the covalent chemical bonds in biological molecules and drug substances. In this chapter we will discuss the various non-covalent interactions that are important in biological molecules and in their interaction with drug molecules. Although non-covalent interactions are typically orders of magnitude weaker than covalent bonds, this does not imply that they are of less importance. As we will see, these “weak” interactions are what give proteins their particular three-dimensional shape and function, enable the copying of genetic information in DNA, and govern the interactions of drug molecules with their biological targets.