RT Book, Section
A1 Renslo, Adam
A2 Renslo, Adam
SR Print(0)
ID 1124842806
T1 Reactions of Carbonyl Species
T2 The Organic Chemistry of Medicinal Agents
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071794213
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1124842806
RD 2024/04/18
AB In  this  chapter  we  explore  the  structure  and  reactivity  of  the  carbonyl  (C=O)  bond  and  related  carbon–heteroatom  (C=X)  double  bonds.  These  functional  groups  are  ubiquitous  in  both  biological  molecules  and  in  the  structures  of  drugs.  A  prominent  example  in  biological  molecules  is  the  amide  bond  (peptide  bond),  which  serves  as  the  structural  backbone  of  proteins  and  also  helps  determine  how  proteins  fold  into  the  specific  three-dimensional  shapes  that  lead  to  function.  Other  biological  molecules  containing  ketone  or  thioester  functions  are  involved  in  cellular  metabolism  and  in  sterol  biosynthesis  in  animals  and  terpene  biosynthesis  in  plants.