RT Book, Section
A1 Joshua, Anthony M.
A1 Boutros, Paul C.
A1 Kislinger, Thomas
A2 Tannock, Ian F.
A2 Hill, Richard P.
A2 Bristow, Robert G.
A2 Harrington, Lea
SR Print(0)
ID 1127471318
T1 Methods of Molecular Analysis
T2 The Basic Science of Oncology, 5e
YR 2016
FD 2016
PB McGraw-Hill Education Medical
PP New York, NY
SN 9780071745208
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127471318
RD 2024/04/24
AB Advances  made  over  the  last  10  years  in  understanding  the  biology  of  cancer  have  transformed  the  field  of  oncology.  While  genetic  analysis  was  limited  previously  to  gross  chromosomal  abnormalities  in  karyotypes,  DNA  in  cells  can  now  be  analyzed  to  the  individual  base  pair  level.  This  intricate  knowledge  of  the  genetics  of  cancer  increases  the  possibility  that  personalized  treatment  for  individual  cancers  lies  in  the  near  future.  To  appreciate  the  relevance  and  nature  of  these  technological  advances,  as  well  as  their  implications  for  function,  an  understanding  of  the  modern  tools  of  molecular  biology  is  essential.  This  chapter  reviews  the  cytogenetic,  nucleic,  proteomic,  and  bioinformatics  methods  used  to  study  the  molecular  basis  of  cancer,  and  highlights  methods  that  are  likely  to  affect  in  the  future  management  of  cancer.