RT Book, Section
A1 Dutt, Previn
A1 Stambolic, Vuk
A2 Tannock, Ian F.
A2 Hill, Richard P.
A2 Bristow, Robert G.
A2 Harrington, Lea
SR Print(0)
ID 1127471920
T1 Oncogenes and Tumor-Suppressor Genes
T2 The Basic Science of Oncology, 5e
YR 2016
FD 2016
PB McGraw-Hill Education Medical
PP New York, NY
SN 9780071745208
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127471920
RD 2024/04/19
AB Cancer  is  fundamentally  a  genetic  disease.  It  results  in  expansion  of  a  cellular  population  that  invades  and  destroys  surrounding  organs  and  tissues  and  gains  the  ability  to  spread  throughout  the  body.  The  second  half  of  the  20th  century  inaugurated  a  steady  stream  of  breakthroughs  in  the  field  of  cancer  research,  largely  spurred  by  an  explosion  of  technologies  enabling  the  analysis  of  tumors  at  a  molecular  level.  Recent  dramatic  advancements  in  low-cost  high-throughput  sequencing  of  cancer  genomes  and  the  development  of  high-resolution  genome-wide  profiling  of  the  changes  in  gene  copy  number  and  structure  are  enabling  detailed  mapping  of  the  genetic  events  associated  with  cellular  transformation  from  nonmalignant  to  malignant  cell.