RT Book, Section
A1 Jorgensen, Paul
A1 Hakem, Razqallah
A2 Tannock, Ian F.
A2 Hill, Richard P.
A2 Bristow, Robert G.
A2 Harrington, Lea
SR Print(0)
ID 1127472195
T1 Cell Proliferation and Death
T2 The Basic Science of Oncology, 5e
YR 2016
FD 2016
PB McGraw-Hill Education Medical
PP New York, NY
SN 9780071745208
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127472195
RD 2024/04/23
AB Our  cells  are  continuously  proliferating  and  dying.  Our  development  from  a  single-celled  egg  into  adults  with  approximately  1014  cells  requires  intense  cell  proliferation.  But  our  development  also  requires  cell  death;  for  instance,  to  prune  excess  neurons  in  the  brain  and  to  sculpt  the  fingers.  As  adults,  most  of  our  organs  exist  in  a  dynamic  steady  state,  being  constantly  renewed  by  cell  proliferation  and  death.  For  example,  our  bodies  generate  and  destroy  more  than  a  million  blood  and  intestinal  cells  every  second.  In  the  extreme,  cells  live  for  only  a  few  days  before  dying,  as  is  the  case  for  neutrophils  and  the  cells  that  line  the  small  intestine.  In  the  midst  of  this  continual  and  profuse  cell  renewal  lies  the  constant  threat  of  cancer.  Cancerous  cells  invariably  contain  alterations  to  genes  encoding  regulators  of  cell  proliferation  and  cell  death  and  are  generally  thought  to  arise  from  actively  proliferating  cell  types.