RT Book, Section A1 Rak, Janusz A2 Tannock, Ian F. A2 Hill, Richard P. A2 Bristow, Robert G. A2 Harrington, Lea SR Print(0) ID 1127472458 T1 Angiogenesis T2 The Basic Science of Oncology, 5e YR 2016 FD 2016 PB McGraw-Hill Education Medical PP New York, NY SN 9780071745208 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127472458 RD 2024/03/29 AB An important feature of malignancies is the associated emergence of new and abnormal contact points between cancer cells and the various facets of the host vascular system (Folkman and Kalluri, 2003; Kerbel, 2008). Prior to transformation many normal epithelial tissues (eg, in the gut, skin, and exocrine glands) are functionally linked to, but often anatomically separated from, the vasculature, for instance, by basement membranes and connective tissue layers (Rak, 2009). These barriers are compromised during the course of the malignant process, resulting in abnormal, often direct and reciprocal interactions between vascular components (endothelial cells, blood cells, plasma, or lymph) and cancer cells at this new tumor–vascular interface.