RT Book, Section
A1 Hilal-Dandan, Randa
A1 Brunton, Laurence L.
SR Print(0)
ID 1127551083
T1 Histamine, Bradykinin, and Their Antagonists
T2 Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071769174
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127551083
RD 2024/04/19
AB Histamine  is  a  major  mediator  of  inflammation,  anaphylaxis,  and  gastric  acid  secretion;  in  addition,  histamine  plays  a  role  in  neurotransmission.  Our  understanding  of  the  physiological  and  pathophysiological  roles  of  histamine  has  been  enhanced  by  the  development  of  subtype-specific  receptor  antagonists  and  by  the  cloning  of  4  receptors  for  histamine.  Competitive  antagonists  of  H1  receptors  are  used  therapeutically  in  treating  allergies,  urticaria,  anaphylactic  reactions,  nausea,  motion  sickness,  insomnia,  and  some  symptoms  of  asthma.  Antagonists  of  the  H2  receptor  are  effective  in  reducing  gastric  acid  secretion.  The  peptide,  bradykinin,  has  cardiovascular  effects  similar  to  those  of  histamine  and  plays  prominent  roles  in  inflammation  and  nociception.