RT Book, Section
A1 Hoffbrand, A. Victor
A2 Longo, Dan L.
SR Print(0)
ID 1135226664
T1 Megaloblastic Anemias
T2 Harrison's Hematology and Oncology, 3e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9781259835834
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1135226664
RD 2024/04/23
AB The  megaloblastic  anemias  are  a  group  of  disorders  characterized  by  the  presence  of  distinctive  morphologic  appearances  of  the  developing  red  cells  in  the  bone  marrow.  The  marrow  is  usually  hypercellular  and  the  anemia  is  based  on  ineffective  erythropoiesis.  The  cause  is  usually  a  deficiency  of  either  cobalamin  (vitamin  B12)  or  folate,  but  megaloblastic  anemia  may  occur  because  of  genetic  or  acquired  abnormalities  that  affect  the  metabolism  of  these  vitamins  or  because  of  defects  in  DNA  synthesis  not  related  to  cobalamin  or  folate  (Table  9-1).  Cobalamin  and  folate  absorption  and  metabolism  are  described  next,  followed  by  the  biochemical  basis,  clinical  and  laboratory  features,  causes,  and  treatment  of  megaloblastic  anemia.