RT Book, Section
A1 Morin, Pat J.
A1 Trent, Jeffrey M.
A1 Collins, Francis S.
A1 Vogelstein, Bert
A2 Longo, Dan L.
SR Print(0)
ID 1135228240
T1 Cancer Genetics
T2 Harrison's Hematology and Oncology, 3e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9781259835834
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1135228240
RD 2024/04/19
AB Cancer  arises  through  a  series  of  somatic  alterations  in  DNA  that  result  in  unrestrained  cellular  proliferation.  Most  of  these  alterations  involve  actual  sequence  changes  in  DNA  (i.e.,  mutations).  They  may  originate  as  a  consequence  of  random  replication  errors,  exposure  to  carcinogens  (e.g.,  radiation),  or  faulty  DNA  repair  processes.  While  most  cancers  arise  sporadically,  familial  clustering  of  cancers  occurs  in  certain  families  that  carry  a  germline  mutation  in  a  cancer  gene.