RT Book, Section A1 Scher, Howard I. A1 Rosenberg, Jonathan E. A1 Motzer, Robert J. A2 Longo, Dan L. SR Print(0) ID 1135229702 T1 Bladder and Renal Cell Carcinomas T2 Harrison's Hematology and Oncology, 3e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9781259835834 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1135229702 RD 2024/10/09 AB Transitional cell epithelium lines the urinary tract from the renal pelvis to the ureter, urinary bladder, and the proximal two-thirds of the urethra. Cancers can occur at any point: 90% of malignancies develop in the bladder, 8% in the renal pelvis, and 2% in the ureter or urethra. Bladder cancer is the fourth most common cancer in men and the thirteenth in women, with an estimated 72,570 new cases and 15,210 deaths in the United States predicted for the year 2013. The almost 5:1 ratio of incidence to mortality reflects the higher frequency of the less lethal superficial variants compared to the more lethal invasive and metastatic variants. The incidence is roughly four times higher in men than in women and twofold higher in white men than in black men, with a median age of 65 years.