RT Book, Section A1 Varadhachary, Gauri R. A1 Abbruzzese, James L. A2 Longo, Dan L. SR Print(0) ID 1135230071 T1 Carcinoma of Unknown Primary T2 Harrison's Hematology and Oncology, 3e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9781259835834 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1135230071 RD 2024/04/19 AB Carcinoma of unknown primary (CUP) is a biopsy-proven malignancy for which the anatomic site of origin remains unidentified after an intensive search. CUP is one of the 10 most frequently diagnosed cancers worldwide, accounting for 3–5% of all cancers. Most investigators limit CUP to epithelial cancers and do not include lymphomas, metastatic melanomas, and metastatic sarcomas because these cancers have specific histology- and stage-based treatments that guide management.