RT Book, Section
A1 Bringhurst, F. Richard
A1 Demay, Marie B.
A1 Krane, Stephen M.
A1 Kronenberg, Henry M.
A2 Jameson, J. Larry
SR Print(0)
ID 1141276538
T1 Bone and Mineral Metabolism in Health and Disease
T2 Harrison's Endocrinology, 4e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259835728
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141276538
RD 2024/04/24
AB Bone  is  a  dynamic  tissue  that  is  remodeled  constantly  throughout  life.  The  arrangement  of  compact  and  cancellous  bone  provides  strength  and  density  suitable  for  both  mobility  and  protection.  In  addition,  bone  provides  a  reservoir  for  calcium,  magnesium,  phosphorus,  sodium,  and  other  ions  necessary  for  homeostatic  functions.  Bone  also  hosts  and  regulates  hematopoiesis  by  providing  niches  for  hematopoietic  cell  proliferation  and  differentiation.  The  skeleton  is  highly  vascular  and  receives  about  10%  of  the  cardiac  output.  Remodeling  of  bone  is  accomplished  by  two  distinct  cell  types:  osteoblasts  produce  bone  matrix,  and  osteoclasts  resorb  the  matrix.