RT Book, Section A1 Bleeker-Rovers, Chantal P. A1 van der Meer, Jos W. M. A2 Kasper, Dennis L. A2 Fauci, Anthony S. SR Print(0) ID 1141405089 T1 FEVER OF UNKNOWN ORIGIN T2 Harrison's Infectious Diseases, 3e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259835971 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141405089 RD 2025/04/29 AB Clinicians commonly refer to any febrile illness without an initially obvious etiology as fever of unknown origin (FUO). Most febrile illnesses either resolve before a diagnosis can be made or develop distinguishing characteristics that lead to a diagnosis. The term FUO should be reserved for prolonged febrile illnesses without an established etiology despite intensive evaluation and diagnostic testing. This chapter focuses on classic FUO in the adult patient.