RT Book, Section
A1 Barshak, Miriam Baron
A1 Kasper, Dennis L.
A2 Kasper, Dennis L.
A2 Fauci, Anthony S.
SR Print(0)
ID 1141406322
T1 INTRAABDOMINAL INFECTIONS AND ABSCESSES
T2 Harrison's Infectious Diseases, 3e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259835971
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141406322
RD 2024/04/23
AB Intraperitoneal  infections  generally  arise  because  a  normal  anatomic  barrier  is  disrupted.  This  disruption  may  occur  when  the  appendix,  a  diverticulum,  or  an  ulcer  ruptures;  when  the  bowel  wall  is  weakened  by  ischemia,  tumor,  or  inflammation  (e.g.,  in  inflammatory  bowel  disease);  or  with  adjacent  inflammatory  processes,  such  as  pancreatitis  or  pelvic  inflammatory  disease,  in  which  enzymes  (in  the  former  case)  or  organisms  (in  the  latter)  may  leak  into  the  peritoneal  cavity.  Whatever  the  inciting  event,  once  inflammation  develops  and  organisms  usually  contained  within  the  bowel  or  another  organ  enter  the  normally  sterile  peritoneal  space,  a  predictable  series  of  events  takes  place.  Intraabdominal  infections  occur  in  two  stages:  peritonitis  and—if  the  patient  survives  this  stage  and  goes  untreated—abscess  formation.  The  types  of  microorganisms  predominating  in  each  stage  of  infection  are  responsible  for  the  pathogenesis  of  disease.