RT Book, Section A1 Gerding, Dale N. A1 Johnson, Stuart A2 Kasper, Dennis L. A2 Fauci, Anthony S. SR Print(0) ID 1141406413 T1 CLOSTRIDIUM DIFFICILE INFECTION, INCLUDING PSEUDOMEMBRANOUS COLITIS T2 Harrison's Infectious Diseases, 3e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259835971 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141406413 RD 2023/12/10 AB Clostridium difficile infection (CDI) is a unique colonic disease that is acquired most often in association with antimicrobial use and the consequent disruption of the normal colonic microbiota. The most commonly diagnosed diarrheal illness acquired in the hospital, CDI results from the ingestion of spores of C. difficile that vegetate, multiply, and secrete toxins, causing diarrhea and pseudomembranous colitis (PMC) in the most severe cases.