RT Book, Section
A1 Ermel, Aaron C.
A1 Brown, Darron R.
A2 Kasper, Dennis L.
A2 Fauci, Anthony S.
SR Print(0)
ID 1141410968
T1 HUMAN PAPILLOMAVIRUS INFECTIONS
T2 Harrison's Infectious Diseases, 3e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259835971
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141410968
RD 2024/10/04
AB Investigation  of  human  papillomavirus  (HPV)  infection  began  in  earnest  in  the  1980s  after  Harold  zur  Hausen  postulated  that  infection  with  these  viruses  was  associated  with  cervical  cancer.  It  is  now  recognized  that  HPV  infection  of  the  human  genital  tract  is  extremely  common  and  causes  clinical  states  ranging  from  asymptomatic  infection  to  genital  warts  (condylomata  acuminata);  dysplastic  lesions  or  invasive  cancers  of  the  anus,  penis,  vulva,  vagina,  and  cervix;  and  a  subset  of  oropharyngeal  cancers.  This  chapter  describes  the  epidemiology  of  HPV  in  general  and  as  a  pathogen,  the  natural  history  of  HPV  infections  and  associated  cancers,  strategies  to  prevent  HPV  infection  and  HPV-associated  disease,  and  treatment  modalities.