RT Book, Section
A1 Kuhn, Jens H.
A2 Kasper, Dennis L.
A2 Fauci, Anthony S.
SR Print(0)
ID 1141412376
T1 EBOLAVIRUS AND MARBURGVIRUS INFECTIONS
T2 Harrison's Infectious Diseases, 3e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259835971
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141412376
RD 2024/04/16
AB Several  viruses  of  the  family  Filoviridae  cause  severe  and  frequently  fatal  viral  hemorrhagic  fevers  in  humans.  Introduction  of  filoviruses  into  human  populations  is  an  extremely  rare  event  that  most  likely  occurs  by  direct  or  indirect  contact  with  healthy  mammalian  filovirus  hosts  or  by  contact  with  infected,  sick,  or  deceased  nonhuman  primates.  Filoviruses  are  highly  infectious  but  not  very  contagious.  Natural  human-to-human  transmission  takes  place  through  direct  person-to-person  (usually  skin-to-skin)  contact  or  exposure  to  infected  bodily  fluids  and  tissues;  there  is  no  evidence  of  such  transmission  by  aerosol  or  respiratory  droplets.  Infections  progress  rapidly  from  influenza-like  to  hemorrhagic  manifestations  and  typically  culminate  in  multiple-organ  dysfunction  syndrome  and  shock.  Treatment  of  filovirus  infections  is  of  necessity  entirely  supportive  because  no  specific  efficacious  antiviral  agents  or  vaccines  are  yet  available.