RT Book, Section A1 Gonzalez, Frank J. A1 Coughtrie, Michael A1 Tukey, Robert H. A2 Brunton, Laurence L. A2 Hilal-Dandan, Randa A2 Knollmann, Björn C. SR Print(0) ID 1162533383 T1 Drug Metabolism T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259584732 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1162533383 RD 2024/03/29 AB AbbreviationsADR: adverse drug reactionAUC: area under the plasma concentration–time curveAZA: azathioprineCAR: constitutive androstane receptorCES2: carboxylesterase 2COMT: catechol-O-methyltransferaseCPT-11: irinotecanCYP: cytochrome P450DPYD: dihydropyrimidine dehydrogenaseEH: epoxide hydrolaseFMO: flavin-containing monooxygenaseGI: gastrointestinalGSH and GSSG: reduced and oxidized glutathioneGST: glutathione-S-transferaseHGPRT: hypoxanthine guanine phosphoribosyl transferaseHIF: hypoxia-inducible factorHIV: human immunodeficiency virusHNMT: histamine N-methyltransferaseHPPH: 5-(-4-hydroxyphenyl)-5-phenylhydantoinINH: isonicotinic acid hydrazide (isoniazid)MAO: monoamine oxidaseMAPK: mitogen-activated protein kinasemEH: microsomal epoxide hydrolase6-MP: 6-mercaptopurineMRP: multidrug resistance proteinMT: methyltransferaseNADPH: nicotinamide adenine dinucleotide phosphateNAPQI:N-acetyl-p-benzoquinone imineNAT:N-acetyltransferaseNNMT: nicotinamide N-methyltransferasePAPS: 3′-phosphoadenosine-5′-phosphosulfatePer: PeriodPgp: P-glycoproteinPNMT: phenylethanolamine N-methyltransferasePOMT: phenol-O-methyltransferasePPAR: peroxisome proliferator–activated receptorPXR: pregnane X receptorRXR: retinoid X receptorSAM:S-adenosyl-methioninesEH: soluble epoxide hydrolaseSULT: sulfotransferaseTBP: TATA box–binding protein6-TGN: 6-thioguanine nucleotideTMA: trimethylamineTPMT: thiopurine methyltransferaseTPT: thiol methyltransferaseUDP-GA: uridine diphosphate–glucuronic acidUGT: uridine diphosphate–glucuronosyltransferase