RT Book, Section
A1 Rogers, John M.
A2 Klaassen, Curtis D.
SR Print(0)
ID 1158498225
T1 Developmental Toxicology
T2 Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th edition
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259863745
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1158498225
RD 2024/04/25
AB Teratology  as  an  empirical  science  has  been  around  for  millennia  and  encompasses  the  study  of  abnormal  structural  development.  Conjoined  twins  have  been  depicted  in  marble  statuary  dating  to  6500  BC  (Warkany,  1983),  and  Egyptian  wall  paintings  of  human  cleft  palate  and  achondroplasia  date  to  5000  years  ago.  The  origin  of  mythological  creatures  including  the  Cyclops  and  sirens  may  have  been  observations  of  malformed  infants  (Thompson,  1930;  Warkany,  1977).  Hippocrates  and  Aristotle  thought  that  physical  agents  such  as  uterine  trauma  or  pressure  could  cause  birth  defects.  Aristotle  also  believed  that  maternal  impressions  and  emotions  could  affect  the  developing  fetus,  and  advised  pregnant  women  to  gaze  at  beautiful  art  to  enhance  their  child's  beauty.  This  idea  is  historically  present  in  diverse  cultures,  and  we  now  understand  that  maternal  stress  or  depression  during  pregnancy  can  be  deleterious  (Dunkel  Schetter  and  Tanner,  2012).