RT Book, Section
A1 Foster, Paul M.D.
A1 Gray, L. Earl
A2 Klaassen, Curtis D.
SR Print(0)
ID 1158501260
T1 Toxic Responses of the Reproductive System
T2 Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th edition
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259863745
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1158501260
RD 2024/04/20
AB Any  evaluation  of  toxicity  to  reproduction  will  consider  those  events  that  may  not  only  have  impact  on  adults’  likelihood  to  have  children,  but  also  impact  the  viability  and  quality  of  life  of  their  potential  offspring  and  may  even  affect  later  generations.  That  chemicals  can  adversely  affect  reproduction  in  males  and  females  is  not  a  new  concept;  one  only  has  to  look  at  the  importance  of  drugs  as  contraceptives  to  realize  how  sensitive  the  reproductive  system  can  be  to  external  chemical  influences  that  disrupt  this  process.  Of  course  in  these  cases,  the  failure  of  normal  reproduction  is  a  desired  outcome  in  a  contraceptive,  but  unfortunately  we  have  had  a  number  of  catastrophes  in  which  such  failure  has  been  unintentional.  Many  of  the  classic  examples  in  chemical  workers,  or  contamination  of  groundwater  from  chemical  exposure  such  as  dibromochloropropane  (DBCP)  or  kepone  (chlordecone)  have  shown  the  sensitivity  of  human  reproduction  to  these  specific  exposures  (reviewed  by  Cannon  et  al.,  1978;  Faroon  et  al.,  1995;  Winker  and  Rudiger,  2006).  There  have  been  significant  improvements  in  our  ability  to  test  for  effects  of  chemicals,  agrochemicals,  and  drugs  on  reproduction,  but  unfortunately  such  adverse  episodes  continue  to  occur,  for  example,  the  recent  reports  of  the  effects  of  2-bromopropane  in  chemical  workers  (both  male  and  female)  in  Korea  (reviewed  by  Boekelheide  et  al.,  2004).