RT Book, Section
A1 Kaplan, Barbara L.F.
A1 Sulentic, Courtney E.W.
A1 Haggerty, Helen G.
A1 Holsapple, Michael P.
A1 Kaminski, Norbert E.
A2 Klaassen, Curtis D.
A2 Watkins, John B.
SR Print(0)
ID 1178014486
T1 Toxic Responses of the Immune System
T2 Casarett & Doull’s Essentials of Toxicology, 4e
YR 2021
FD 2021
PB McGraw Hill
PP New York, NY
SN 9781260452297
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1178014486
RD 2024/04/19
AB KEY  POINTSImmunity  is  a  series  of  delicately  balanced,  complex,  multicellular,  and  physiologic  mechanisms  that  allow  an  individual  to  distinguish  foreign  material  from  “self”  and  to  neutralize  and/or  eliminate  that  foreign  matter.Innate  immunity,  which  eliminates  most  potential  pathogens  before  significant  infection  occurs,  includes  physical  and  biochemical  barriers  both  inside  and  outside  of  the  body  as  well  as  immune  cells  designed  for  specific  responses.Acquired  immunity  involves  producing  a  specific  immune  response  to  each  infectious  agent  (specificity)  and  remembering  that  agent  so  as  to  mount  a  faster  response  to  a  future  infection  by  the  same  agent  (memory).Autoimmunity  occurs  when  the  reactions  of  the  immune  system  are  directed  against  the  body’s  own  tissues,  resulting  in  tissue  damage  and  disease.Hypersensitivity  reactions  require  prior  exposure  leading  to  sensitization  in  order  to  elicit  a  reaction  on  subsequent  challenge.Immunotoxicology  is  the  study  of  adverse  effects  of  drugs,  environmental  chemicals,  and,  in  some  instances,  biological  materials  on  the  immune  system  resulting  from  occupational,  inadvertent,  or  therapeutic  exposure.Xenobiotics  that  alter  the  immune  system  can  upset  the  balance  between  immune  recognition  and  destruction  of  foreign  invaders  and  the  proliferation  of  these  microbes  and/or  cancer  cells.