RT Book, Section
A1 Leikauf, George D.
A2 Klaassen, Curtis D.
A2 Watkins, John B.
SR Print(0)
ID 1178014945
T1 Toxic Responses of the Respiratory System
T2 Casarett & Doull’s Essentials of Toxicology, 4e
YR 2021
FD 2021
PB McGraw Hill
PP New York, NY
SN 9781260452297
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1178014945
RD 2024/04/18
AB KEY  POINTSInhaled  xenobiotics  can  affect  lung  tissues  directly  or  distant  organs  after  absorption.Water  solubility  is  a  decisive  factor  in  determining  how  deeply  a  given  gas  penetrates  into  the  lung.Particle  size  is  usually  the  critical  factor  that  determines  the  region  of  the  respiratory  tract  in  which  a  particle  or  an  aerosol  will  deposit.The  lung  contains  most  of  the  enzymes  involved  in  xenobiotic  biotransformation  that  have  been  identified  in  other  tissues.Asthma  is  characterized  by  increased  reactivity  of  the  bronchial  smooth  muscle  in  response  to  exposure  to  irritants.In  emphysema,  destruction  of  the  gas-exchanging  surface  area  results  in  a  distended,  hyperinflated  lung  that  no  longer  effectively  exchanges  oxygen  and  carbon  dioxide.