RT Book, Section
A1 Warheit, David B.
A1 Oberdörster, Günter
A1 Kane, Agnes B.
A1 Brown, Scott C.
A1 Klaper, Rebecca D.
A1 Hurt, Robert H.
A2 Klaassen, Curtis D.
A2 Watkins, John B.
SR Print(0)
ID 1178017437
T1 Nanoparticle Toxicology
T2 Casarett & Doull’s Essentials of Toxicology, 4e
YR 2021
FD 2021
PB McGraw Hill
PP New York, NY
SN 9781260452297
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1178017437
RD 2025/04/23
AB KEY  POINTSNanotechnology  is  the  understanding  and  control  of  matter  at  nanoscale  dimensions  between  approximately  1  and  100  nm,  where  unique  phenomena  enable  novel  applications.Nanotoxicology  can  be  defined  as  the  study  of  adverse  effects  of  nanomaterials  on  living  organisms  and  the  environment.Surface  properties  are  major  determinants  of  biological  reactivity  due  to  high  surface  area,  surface  charge,  dissolution  and  release  of  metal  ions,  and  redox  activity  leading  to  generation  of  reactive  oxygen  species  (ROS).The  respiratory  tract  is  the  major  route  for  humans  to  exposure  of  nanomaterials.Surface  properties  are  major  determinants  of  biological  reactivity  due  to  high  surface  area,  surface  charge,  hydrophobicity  and  partitioning  into  lipid  membranes,  dissolution  and  release  of  metal  ions,  and  redox  activity.Dosemetric  defines  a  dose  in  terms  of  an  inherent  property  (physical,  chemical,  reactivity,  etc.)