RT Book, Section
A1 Boutros, Paul C.
A1 Harrington, Lea
A1 Kislinger, Thomas
A2 Harrington, Lea A.
A2 Tannock, Ian F.
A2 Hill, Richard P.
A2 Cescon, David W.
SR Print(0)
ID 1179323269
T1 Methods of Molecular Analysis
T2 The Basic Science of Oncology, 6e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781259862076
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1179323269
RD 2022/08/17
AB Advances  in  understanding  the  biology  of  cancer  have  transformed  the  field  of  oncology.  Although  genetic  analysis  was  limited  previously  to  gross  chromosomal  abnormalities  in  karyotypes,  DNA  and  RNA  in  cells  can  now  be  analyzed  at  the  individual  base-pair  level,  and  there  is  increasing  knowledge  about  the  structure  and  interactions  of  proteins.  This  intricate  knowledge  of  the  molecular  properties  of  cancer  increases  the  possibility  that  personalized  treatment  for  individual  cancers  might  be  achieved.  To  appreciate  the  relevance  and  nature  of  these  technological  advances,  as  well  as  their  implications  for  function,  an  understanding  of  the  modern  tools  of  molecular  biology  is  essential.  This  chapter  reviews  the  cytogenetic,  nucleic,  proteomic,  and  bioinformatics  methods  used  to  study  the  molecular  basis  of  cancer,  and  highlights  methods  that  are  likely  to  affect  its  future  management.