RT Book, Section A1 Dutt, Previn A1 Stambolic, Vuk A2 Harrington, Lea A. A2 Tannock, Ian F. A2 Hill, Richard P. A2 Cescon, David W. SR Print(0) ID 1179323869 T1 Oncogenes and Tumor-Suppressor Genes T2 The Basic Science of Oncology, 6e YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781259862076 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1179323869 RD 2024/03/28 AB Cancer is fundamentally driven by genetic changes in normal cells that result in the acquisition of transformative malignant properties. These mutations permit the uncontrolled replication of the transformed cancer cells, a small fraction of which ultimately gains the ability to leave their tissue of origin and invade distant parts of the body where metastatic lesions are established. The second half of the 20th century witnessed a steady stream of breakthroughs in the field of cancer research, largely spurred by an explosion of technologies facilitating the analysis of tumors at a molecular level. Recent advances in low-cost high-throughput sequencing of cancer genomes (Chap. 2) are enabling a detailed mapping of the genetic events associated with the transformation of nonmalignant cells to metastatic cancer cells.