RT Book, Section
A1 Rak, Janusz
A1 Emmenegger, Urban
A2 Harrington, Lea A.
A2 Tannock, Ian F.
A2 Hill, Richard P.
A2 Cescon, David W.
SR Print(0)
ID 1179324431
T1 Angiogenesis
T2 The Basic Science of Oncology, 6e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781259862076
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1179324431
RD 2024/04/20
AB An  important  feature  of  malignancies  is  the  emergence  of  new  and  abnormal  contact  points  between  cancer  cells  and  the  host  vascular  system  (Folkman,  2007).  Prior  to  transformation,  many  epithelial  tissues  (eg,  in  the  gut,  skin,  and  exocrine  glands)  are  anatomically  separated  from  the  vasculature  by  basement  membranes  and/or  connective  tissue  layers.  These  barriers  are  compromised  during  the  malignant  process,  resulting  in  abnormal  interactions  between  vascular  components  (endothelial  cells,  blood  cells,  plasma,  or  lymph)  and  cancer  cells  at  this  new  tumor-vascular  interface  (Rak,  2009).