RT Book, Section A1 Gedye, Craig A2 Harrington, Lea A. A2 Tannock, Ian F. A2 Hill, Richard P. A2 Cescon, David W. SR Print(0) ID 1179324803 T1 Cancer Heterogeneity T2 The Basic Science of Oncology, 6e YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781259862076 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1179324803 RD 2024/03/29 AB Every patient’s cancer is different. Cancers arising from the same organ may have different histology and metastatic potential, may be indolent or aggressive, and may have different response to therapy. Cells within a cancer are also different. Within individual tumors, some cells are genetically normal stromal cells and some are somatically-mutated malignant cells. And within the malignant cell pool, related but differently evolved malignant clones vie for survival, exploiting different epigenetic strategies, within different microenvironments within each tumor (Fig. 13–1; see Chap. 12, Sec. 12.2).