RT Book, Section A1 Kandel, Eric R. A1 Koester, John D. A1 Mack, Sarah H. A1 Siegelbaum, Steven A. SR Print(0) ID 1180646867 T1 Disorders of Mood and Anxiety T2 Principles of Neural Science, 6e YR 2021 FD 2021 PB McGraw Hill PP New York, NY SN 9781259642234 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1180646867 RD 2022/05/20 AB DEPRESSION, BIPOLAR DISORDER, AND ANXIETY DISORDERS have been well documented in medical writings since ancient times. In the fifth century BC, Hippocrates taught that moods depended on the balance of four humors—blood, phlegm, yellow bile, and black bile. An excess of black bile (melancholia is the ancient Greek term for black bile) was believed to cause a state dominated by fear and despondency. Robert Burton’s Anatomy of Melancholy (1621) was not only an important medical text but also viewed literature and the arts through the lens of melancholia. Such texts describe symptoms that remain familiar today; they also recognized that symptoms of depression and of anxiety often occur together.