RT Book, Section A1 Bigelow, Robert A2 Lopes, Renato D. A2 Harrington, Robert A. SR Print(0) ID 57835465 T1 Chapter 5. Introduction to Clinical Experimentation T2 Understanding Clinical Research YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-174678-6 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=57835465 RD 2024/04/20 AB The practice of medicine is an art, performed for the healing and reduction in suffering of individual patients. Doctors practice their art through skilled application of available medical knowledge. Before the scientific and technological advances made in the last century, medical knowledge belonged to a select few and was passed from teachers to students as if from parents to children (see the first point in the Hippocratic Oath) (1). Although much had been learned through careful observation of human anatomy and disease, empirical evidence on prognoses and treatment outcomes was limited. Rational treatment decisions could be made deductively or on the basis of accepted beliefs; however, the inability to obtain extensive empirical evidence left the value of many treatments unproven and poorly understood.