RT Book, Section A1 Eaton, David L. A1 Gilbert, Steven G. SR Print(0) ID 1100084201 T1 Principles of Toxicology T2 Casarett and Doull's Toxicology: The Basic Science of Poisons, 8e YR 2012 FD 2012 PB McGraw-Hill Education PP New York, NY SN 978-0-07-176925-9 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1100084201 RD 2024/03/28 AB Introduction to ToxicologyDifferent Areas of ToxicologyToxicology and SocietyGeneral Characteristics of the Toxic ResponseClassification of Toxic AgentsSpectrum of Undesired EffectsAllergic ReactionsIdiosyncratic ReactionsImmediate versus Delayed ToxicityReversible versus Irreversible Toxic EffectsLocal versus Systemic ToxicityInteraction of ChemicalsToleranceCharacteristics of ExposureRoute and Site of ExposureDuration and Frequency of ExposureDose–Response RelationshipIndividual, or Graded, Dose–Response RelationshipsQuantal Dose–Response RelationshipsShape of the Dose–Response CurveEssential NutrientsHormesisThresholdNonmonotonic Dose–Response CurvesAssumptions in Deriving the Dose–Response RelationshipEvaluating the Dose–Response RelationshipComparison of Dose ResponsesTherapeutic IndexMargins of Safety and ExposurePotency versus EfficacyVariation in Toxic ResponsesSelective ToxicitySpecies DifferencesIndividual Differences in ResponseDescriptive Animal Toxicity TestsAcute Toxicity TestingSkin and Eye IrritationsSensitizationSubacute (Repeated-Dose Study)SubchronicChronicDevelopmental and Reproductive ToxicityMutagenicityOncogenicity BioassaysNeurotoxicity AssessmentImmunotoxicity AssessmentOther Descriptive Toxicity TestsToxicogenomicsGenomicsEpigenetics/EpigenomicsTranscriptomicsProteomicsMetabonomics/MetabolomicsBioinformaticsChallenges in Using “Omics” Technologies for Predictive Toxicology and Risk Assessment