RT Book, Section SR Print(0) ID 1101677711 T1 Propagated Signaling: The Action Potential T2 Principles of Neural Science, Fifth Edition YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 978-0-07-139011-8 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1101677711 RD 2024/03/28 AB The Action Potential Is Generated by the Flow of Ions Through Voltage-Gated ChannelsSodium and Potassium Currents Through Voltage-Gated Channels Are Recorded with the Voltage ClampVoltage-Gated Sodium and Potassium Conductances Are Calculated from Their CurrentsThe Action Potential Can Be Reconstructed from the Properties of Sodium and Potassium ChannelsVariations in the Properties of Voltage-Gated Ion Channels Expand the Signaling Capabilities of NeuronsThe Nervous System Expresses a Rich Variety of Voltage-Gated Ion ChannelsGating of Voltage-Sensitive Ion Channels Can Be Influenced by Various Cytoplasmic FactorsExcitability Properties Vary Between Regions of the NeuronExcitability Properties Vary Between Types of NeuronsThe Mechanisms of Voltage-Gating and Ion Permeation Have Been Inferred from Electrophysiological MeasurementsVoltage-Gated Sodium Channels Open and Close in Response to Redistribution of Charges Within the ChannelVoltage-Gated Sodium Channels Select for Sodium on the Basis of Size, Charge, and Energy of Hydration of the IonVoltage-Gated Potassium, Sodium, and Calcium Channels Stem from a Common Ancestor and Have Similar StructuresX-Ray Crystallographic Analysis of Voltage-Gated Channel Structures Provides Insight into Voltage-GatingThe Diversity of Voltage-Gated Channel Types Is Generated by Several Genetic MechanismsAn Overall View