RT Book, Section SR Print(0) ID 1101683085 T1 Patterning the Nervous System T2 Principles of Neural Science, Fifth Edition YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 978-0-07-139011-8 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1101683085 RD 2024/10/09 AB The Neural Tube Becomes Regionalized Early in EmbryogenesisSecreted Signals Promote Neural Cell FateDevelopment of the Neural Plate Is Induced by Signals from the Organizer RegionNeural Induction Is Mediated by Peptide Growth Factors and Their InhibitorsRostrocaudal Patterning of the Neural Tube Involves Signaling Gradients and Secondary Organizing CentersSignals from the Mesoderm and Endoderm Define the Rostrocaudal Pattern of the Neural PlateSignals from Organizing Centers within the Neural Tube Pattern the Forebrain, Midbrain, and HindbrainDorsoventral Patterning of the Neural Tube Involves Similar Mechanisms at Different Rostrocaudal LevelsThe Ventral Neural Tube Is Patterned by Sonic Hedgehog Protein Secreted from the Notochord and Floor PlateThe Dorsal Neural Tube Is Patterned by Bone Morphogenetic ProteinsDorsoventral Patterning Mechanisms Are Conserved Along the Rostrocaudal Extent of the Neural TubeLocal Signals Determine Functional Subclasses of NeuronsRostrocaudal Position Is a Major Determinant of Motor Neuron SubtypeLocal Signals and Transcriptional Circuits Further Diversify Motor Neuron SubtypesThe Developing Forebrain Is Patterned by Intrinsic and Extrinsic InfluencesInductive Signals and Transcription Factor Gradients Establish Regional DifferentiationAfferent Inputs Also Contribute to RegionalizationAn Overall View