RT Book, Section A1 Joy, Tisha R. A1 Hegele, Robert A. A2 Murray, Michael F. A2 Babyatsky, Mark W. A2 Giovanni, Monica A. A2 Alkuraya, Fowzan S. A2 Stewart, Douglas R. SR Print(0) ID 1102698790 T1 Metabolic Syndrome T2 Clinical Genomics: Practical Applications in Adult Patient Care YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 9780071622448 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1102698790 RD 2024/11/09 AB Disease summary:Metabolic syndrome (MetS) is a complex genetic disorder, involving the interaction of multiple genetic loci with environmental factors.MetS consists of three of the five following criteria: increased waist circumference (Table 12-1); triglyceride (TG) level greater than or equal to 150 mg/dL (1.7 mmol/L) or drug treatment for elevated TG; high-density lipoprotein-cholesterol (HDL-C) less than 40 mg/dL (1 mmol/L) in males or less than 50 mg/dL (1.3 mmol/L) in females or drug treatment for reduced HDL-C level; systolic blood pressure (SBP) greater than or equal to 130 mm Hg and/or diastolic blood pressure (DBP) greater than or equal to 85 mm Hg or antihypertensive drug treatment in a patient with a history of elevated blood pressure (BP); fasting glucose greater than or equal to 100 mg/dL (5.6 mmol/L) or drug treatment for elevated glucose.Individuals with MetS have a twofold increased risk for cardiovascular disease (CVD) and fivefold increased risk for type 2 diabetes (DM2) compared to individuals without MetS.