RT Book, Section A1 L. Kujovich, Jody A2 Murray, Michael F. A2 Babyatsky, Mark W. A2 Giovanni, Monica A. A2 Alkuraya, Fowzan S. A2 Stewart, Douglas R. SR Print(0) ID 1102699126 T1 Thrombophilia T2 Clinical Genomics: Practical Applications in Adult Patient Care YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 9780071622448 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1102699126 RD 2024/03/29 AB Disease summary:The term thrombophilia refers to an inherited or acquired predisposition to thromboembolism.Inherited thrombophilias include deficiencies of the three natural anticoagulant proteins antithrombin (AT), protein C (PC), and protein S (PS), and specific mutations in the genes for factor V (factor V Leiden) and prothrombin (prothrombin 20210G>A).Inherited thrombophilias increase the risk for a first venous thromboembolism (VTE) 2- to 20-fold but are not major risk factors for arterial thromboembolism.Although the risks vary, inherited thrombophilias are not strongly predictive of recurrent VTE after an initial episode.The clinical expression of an inherited thrombophilia reflects a complex interplay between genetic and acquired risk factors.