RT Book, Section
A1 Kuivaniemi, S. Helena
A1 C. Tromp, Gerard
A1 Hinterseher, Irene
A1 Carey, David J.
A2 Murray, Michael F.
A2 Babyatsky, Mark W.
A2 Giovanni, Monica A.
A2 Alkuraya, Fowzan S.
A2 Stewart, Douglas R.
SR Print(0)
ID 1102699743
T1 Abdominal Aortic Aneurysm
T2 Clinical Genomics: Practical Applications in Adult Patient Care
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071622448
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1102699743
RD 2024/04/19
AB Disease  summary:Abdominal  aortic  aneurysms  (AAAs),  defined  as  dilatations  of  the  aorta,  are  a  complex  disease  with  both  genetic  and  environmental  risk  factors.Prevalence:  1%  to  2%  of  Caucasian  populations  harbor  AAAs  in  industrialized  countries.  Prevalence  increases  with  age  to  about  10%  among  men  over  65  years  of  age.AAA  is  the  17th  leading  cause  of  death  in  the  United  States,  with  approximately  15,000  deaths  per  year.Risk  factors:  The  most  important  known  risk  factors  are  smoking,  positive  family  history,  advanced  age,  and  male  sex.  Elevated  cholesterol  levels  and  hypertension  are  mild  risk  factors.  Diabetes,  African-American  ethnicity,  and  female  sex  are  protective  factors.AAAs  have  a  complex,  poorly  understood  pathophysiology,  in  which  inflammation,  smooth  muscle  cell  apoptosis,  reactive  oxygen  species,  extracellular  matrix  degradation,  and  activation  of  matrix  metalloproteinases  play  a  role.