RT Book, Section
A1 Braggio, Esteban
A1 Fonseca, Rafael
A2 Murray, Michael F.
A2 Babyatsky, Mark W.
A2 Giovanni, Monica A.
A2 Alkuraya, Fowzan S.
A2 Stewart, Douglas R.
SR Print(0)
ID 1102700116
T1 Multiple Myeloma and Other Plasma Cell Disorders
T2 Clinical Genomics: Practical Applications in Adult Patient Care
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071622448
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1102700116
RD 2024/04/25
AB Disease  summary:Multiple  myeloma  (MM)  is  a  plasma  cell  malignancy  characterized  by  accumulation  of  clonal  antibody-secreting  plasma  cells.MM  accounts  for  1%  of  all  cancers  and  10%  of  all  hematologic  malignancies.Almost  all  MM  evolves  from  an  asymptomatic  premalignant  stage  termed  as  monoclonal  gammopathy  of  undetermined  significance  (MGUS).MM  is  now  believed  to  be  curable  in  only  a  small  fraction  of  cases,  and  has  a  median  overall  survival  of  5  years.The  major  clinical  manifestations  are  bone  lesions,  anemia,  hypercalcemia,  renal  failure,  and  an  increased  risk  of  infections.Genetic  abnormalities  are  used  for  disease  risk  stratification  and  therapeutic  decision  making.