RT Book, Section
A1 Nishizawa, Haruki
A1 Kurahashi, Hiroki
A2 Murray, Michael F.
A2 Babyatsky, Mark W.
A2 Giovanni, Monica A.
A2 Alkuraya, Fowzan S.
A2 Stewart, Douglas R.
SR Print(0)
ID 1102703673
T1 Recurrent Pregnancy Loss
T2 Clinical Genomics: Practical Applications in Adult Patient Care
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071622448
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1102703673
RD 2024/04/24
AB Disease  summary:Recurrent  pregnancy  loss  (RPL)  is  traditionally  defined  as  three  or  more  consecutive  losses  of  recognized  pregnancies  in  the  first  or  early  second  trimester  (<20  weeks  of  gestation).  Sporadic  spontaneous  pregnancy  loss  occurs  randomly  in  one-sixth  of  clinically  recognized  pregnancies.  However,  RPL  must  be  distinguished  from  sporadic  cases  as  these  occasionally  respond  to  treatment.  Around  1%  of  couples  attempting  pregnancy  experience  RPL.Hereditary  basis:Structural  chromosomal  abnormalities  such  as  translocations  and  inversions  are  often  identified  in  one  partner  of  a  couple  experiencing  RPL.  The  fetuses  from  these  couples  frequently  carry  chromosome  copy  number  abnormalities  which  lead  to  miscarriage.  Hereditary  thrombophilia  in  females  is  also  occasionally  associated  with  RPL.Differential  diagnosis:RPL  is  a  heterogeneous  condition.  In  addition  to  parental  chromosomal  abnormalities  and  hereditary  thrombophilia,  hormonal  and  metabolic  disorders,  uterine  anatomic  abnormalities,  certain  infections,  and  autoimmune  disorders  have  been  accepted  as  etiologic  factors  in  RPL.  However,  up  to  50%  of  these  cases  still  remain  unexplained  after  standard  gynecologic,  hormonal,  and  karyotypic  investigations.