RT Book, Section A1 Leikauf, George D. A2 Klaassen, Curtis D. A2 Watkins III, John B. SR Print(0) ID 1113950441 T1 Toxic Responses of the Respiratory System T2 Casarett & Doull’s Essentials of Toxicology, 3e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071847087 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1113950441 RD 2024/03/29 AB Inhaled xenobiotics can affect lung tissues directly or distant organs after absorption.Water solubility is a decisive factor in determining how deeply a given gas penetrates into the lung.Particle size is usually the critical factor that determines the region of the respiratory tract in which a particle or an aerosol will deposit.The lung contains most of the enzymes involved in xenobiotic biotransformation that have been identified in other tissues.Asthma is characterized by increased reactivity of the bronchial smooth muscle in response to exposure to irritants.In emphysema, destruction of the gas-exchanging surface area results in a distended, hyperinflated lung that no longer effectively exchanges oxygen and carbon dioxide.