RT Book, Section A1 Rice, Robert H. A1 Mauro, Theodora M. A2 Klaassen, Curtis D. A2 Watkins III, John B. SR Print(0) ID 1113951002 T1 Toxic Responses of the Skin T2 Casarett & Doull’s Essentials of Toxicology, 3e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071847087 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1113951002 RD 2024/03/28 AB The skin participates directly in thermal, electrolyte, hormonal, metabolic, and immune regulation.Percutaneous absorption depends on the xenobiotic’s hydrophobicity, which affects its ability to partition into epidermal lipid, and rate of diffusion through this barrier.The cells of the epidermis and pilosebaceous units express biotransformation enzymes.Irritant dermatitis is a nonimmune-related response caused by the direct action of an agent on the skin.Allergic contact dermatitis represents a delayed (type IV) hypersensitivity reaction, whereby minute quantities of material elicit overt reactions.