RT Book, Section
A1 Foster, Paul M.D.
A1 Gray, L. Earl
A2 Klaassen, Curtis D.
A2 Watkins III, John B.
SR Print(0)
ID 1113951172
T1 Toxic Responses of the Reproductive System
T2 Casarett & Doull’s Essentials of Toxicology, 3e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071847087
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1113951172
RD 2024/04/24
AB The  gonads  possess  a  dual  function:  an  endocrine  function  involving  the  secretion  of  sex  hormones  and  a  nonendocrine  function  relating  to  the  production  of  germ  cells  (gametogenesis).Gametogenic  and  secretory  functions  of  either  the  ovary  or  testes  are  dependent  on  the  secretion  of  follicle-stimulating  hormone  (FSH)  and  luteinizing  hormone  (LH)  from  the  pituitary.The  blood–testis  barrier  between  the  lumen  of  an  interstitial  capillary  and  the  lumen  of  a  seminiferous  tubule  impedes  or  prevents  the  free  exchange  of  chemicals/drugs  between  the  blood  and  the  fluid  inside  the  seminiferous  tubules.Xenobiotics  can  act  directly  on  the  hypothalamus  and  the  adenohypophysis,  leading  to  alterations  in  the  secretion  of  hypothalamic-releasing  hormones  and/or  gonadotropins.Steroid  hormone  biosynthesis  can  occur  in  several  endocrine  organs  including  the  adrenal  cortex,  ovary,  and  the  testes.Female  reproductive  processes  of  oogenesis,  ovulation,  the  development  of  sexual  receptivity,  coitus,  gamete  and  zygote  transport,  fertilization,  and  implantation  of  the  conceptus  may  be  sites  of  xenobiotic  interference.Xenobiotics  may  influence  male  reproductive  organ  structure,  spermatogenesis,  androgen  hormone  secretion,  and  accessory  organ  function.